Accessing Super High Resolution Without Compromise
Julien Savatovsky, MD
Dr Julien Savatovsky, a Neuroradiologist and the Deputy Head of Diagnostic Neuroradiology at Rothschild Foundation Hospital, Paris, France, uses advanced image reconstructions solutions, based on Artificial Intelligence (AI), in his daily routine. Collaborating closely with Canon Medical, he has contributed to the development of the latest reconstruction algorithms and evaluated them on the Hospital’s Vantage Orian 1.5T and Vantage Galan 3T MRI systems. This experience has convinced Dr. Savatovsky that AI can challenge the well-known ‘triangle of compromise’ in imaging between signal-to-noise ratio (SNR), spatial resolution, and acquisition time.
From left to right: Julien Savatovsky, MD, Fabienne Rabeau, Emilie Poirion, PhD, Elsa Guibert, Cloé Guillaume, Jean-Claude Sadik, MD, Dilara Tassoit, Augustin Lecler, PU-PH
The Rothschild Foundation Hospital is a non-profit hospital in Paris, which pioneers care, research, and cooperation on eye and brain diseases. The Neuroradiology Department at the Hospital is continually involved in advancing research through the use of cutting-edge imaging techniques.
Canon’s Advanced intelligent Clear-IQ Engine (AiCE) was the first AI-based denoising solution made available for CT and MR imaging. It is a very robust solution that achieves high SNR images by selectively removing noise without affecting the signal coming from tissues.
Following the strong success of AiCE, Canon have recently released Precise IQ Engine (PIQE) - a new solution developed to increase image sharpness and gain in diagnostic confidence. Using several algorithms, PIQE removes noise, increases matrix size, and reduces Gibbs ringing artifacts. It produces sharp anatomical images that take MR imaging to the next level.
Following the strong success of AiCE, Canon have recently released Precise IQ Engine (PIQE) - a new solution developed to increase image sharpness and gain in diagnostic confidence. Using several algorithms, PIQE removes noise, increases matrix size, and reduces Gibbs ringing artifacts. It produces sharp anatomical images that take MR imaging to the next level.
‘Triangle of compromise’
“Image quality is crucial in diagnosis because it's what drives the confidence in the radiologist's diagnostics and the clinician’s confidence in the radiologist,” remarked Dr. Savatovsky.
“There are many subjective issues in the assessment of image quality and few objective measurements that we can do, including signal-to-noise ratio (SNR), spatial resolution contrast and contrast to noise ratio (CNR),” he continued. “Therein, lies what I call the ‘triangle of compromise’ that has ‘haunted’ MRI in that, for a given sequence you have a given time, a given SNR, and a given spatial resolution. If you adjust for better spatial resolution, for example, the consequences are two compromises - one on SNR that will go down and one other on the acquisition time that will be longer.”
Dr. Savatovsky has explored the impact of Deep Learning Reconstruction (DLR) techniques, such as Canon’s Advanced intelligent Clear-IQ Engine (AiCE) and the latest Precise IQ Engine (PIQE), in adressing these compromises.
“There are many subjective issues in the assessment of image quality and few objective measurements that we can do, including signal-to-noise ratio (SNR), spatial resolution contrast and contrast to noise ratio (CNR),” he continued. “Therein, lies what I call the ‘triangle of compromise’ that has ‘haunted’ MRI in that, for a given sequence you have a given time, a given SNR, and a given spatial resolution. If you adjust for better spatial resolution, for example, the consequences are two compromises - one on SNR that will go down and one other on the acquisition time that will be longer.”
Dr. Savatovsky has explored the impact of Deep Learning Reconstruction (DLR) techniques, such as Canon’s Advanced intelligent Clear-IQ Engine (AiCE) and the latest Precise IQ Engine (PIQE), in adressing these compromises.
“Nowadays, Deep Learning technologies can be found in post-processing field, adding an extra layer to the reconstructed images, improving their quality", he said. "During years, we improved the SNR using filters, but it was at the cost of the image sharpness, due to the introduction of important blurring effects. And at the opposite, if we wanted a crisper image, we used high filter which also increase the noise. Now, thanks to Deep Learning recontructions such as AiCE, we have the possibility to improve SNR without compromising the sharpness of the images.”
“In the below image, there is a small Multiple Sclerosis (MS) lesion of the posterior fossa that is very important to detect because it's usually enough to cause very significant symptoms,” explained Dr. Savatovsky. “The lesion is much more visible with AiCE technology thanks to contrast-to-noise ratio improvement.”
“In the below image, there is a small Multiple Sclerosis (MS) lesion of the posterior fossa that is very important to detect because it's usually enough to cause very significant symptoms,” explained Dr. Savatovsky. “The lesion is much more visible with AiCE technology thanks to contrast-to-noise ratio improvement.”
Figure 1: 3D FLAIR brain images for a multiple sclerosis patient follow-up between 2020 and 2022. AICE reconstructions allow a better delineation of posterior fossa lesions (white arrows)
Figure 2: Sagittal 3D FLAIR brainstem images for a multiple slerosis patient follow-up between 2020 and 2022. AiCE reconstructions allow a better delineation of the brainstem and the cervical spinal cord lesions (white arrows)
“This cervical spinal cord lesion was not really visible previously. But with this one millimeter isotropic FLAIR reconstructed with AiCE, it was clearly visible without any doubts. By applying such reconstruction algorithm on 3D sequences, we get the benefits of the AI-based denoising in every planes," said Dr. Savatovsky.
Figure 2: Sagittal 3D FLAIR brainstem images for a multiple slerosis patient follow-up between 2020 and 2022. AiCE reconstructions allow a better delineation of the brainstem and the cervical spinal cord lesions (white arrows)
"The same patient had an optic neuritis. This is usually very challenging to observe it on a FLAIR sequence because of the low SNR that we get in this difficult region. Once again, AiCE allows the inflammation visualization despite the very high resolution, emphasizing the power of the algorithm," remarked Dr. Savatovsky.
Figure 3: 3D FLAIR brain images for a multiple sclerosis patient with a left optic neuritis. AiCE reconstructions allow a better visualization of the inflamed optical nerve (white arrows)
Figure 4: Coronal 2D T2w brain images with a 300 x 300 μm² in-plane resolution for a patient with optic neuritis. AiCE reconstructions allow a SNR and a better visualization of the inflamed optical nerve (white arrows)
“This is an image created in three minutes with 300 Micron voxels on a different patient with a right optic neuritis. We want the voxel to be very small, but we end up with a very noisy image if we use common filters. When we apply Deep Learning reconstructions, we can see the optic neuritis really well and we recover some SNR and some CNR,” he added.
Figure 4: Coronal 2D T2w brain images with a 300 x 300 μm² in-plane resolution for a patient with optic neuritis. AiCE reconstructions allow a SNR and a better visualization of the inflamed optical nerve (white arrows)
Closing quality gaps
An other advantage of AiCE and PIQE is that they can help to close image quality gaps between systems, when a healthcare facility has different devices, such as 1.5T and 3T MRI systems.
“Thanks to the improvement in SNR, we can really enhance the image quality and get the same quality at 1.5T than the one we have at 3T,” said Dr. Savatovsky. “Just recently, I obtained an 800 micron isotropic image with a very high image quality at 1.5T, which we can usually only achieve on 3T systems.”
“Thanks to the improvement in SNR, we can really enhance the image quality and get the same quality at 1.5T than the one we have at 3T,” said Dr. Savatovsky. “Just recently, I obtained an 800 micron isotropic image with a very high image quality at 1.5T, which we can usually only achieve on 3T systems.”
Dr Savatovsky and his team have performed a study to explore the image improvements allowed by DLR.
“We've proven on MS patients that both the SNR and the CNR were better with DLR. In addition, the stronger the DLR algorithm, the better the results,” he said. “Now, the ‘triangle of compromise’ is totally reconsidered. Using Deep Learning algorithms, we can improve the SNR, without compromise on spatial resolution and keeping the same scan time.”
“We've proven on MS patients that both the SNR and the CNR were better with DLR. In addition, the stronger the DLR algorithm, the better the results,” he said. “Now, the ‘triangle of compromise’ is totally reconsidered. Using Deep Learning algorithms, we can improve the SNR, without compromise on spatial resolution and keeping the same scan time.”
Figure 5: Axial 2D T2w images of a multiple sclerosis patient with a 600 x 600 μm² in-plane resolution. A zoom has been done on a lesion, to appreciate the highest definition and denoising obtained with PIQE reconstruction.
The power of PIQE
Figure 6: Sagittal T2w Dixon images of a 71-year-old patient with cervical spondylotic myelopathy after surgery. The spinal cord residual high-T2 signal abnormalities in C2-C3, C3-C4 and C4-C5 are better depicted on the PIQE reconstructions. In addition, the sharpness of vertebræ, discs and spinal cord has been highly improved.
The team has also explored further by enhancing matrix resolution and image sharpness using PIQE.
“The first result that we've obtained using PIQE – which is currently only applicable on 2D MRI sequences – is that you can obtain sharper images without altering the SNR. We get now crisper images," said Dr Savatovsky.
“We feel that we get far more details, which is quite surprising, because it's the same acquisition and the same scan time. In addition of improving SNR, PIQE also increases the matrix resolution, facilitating contour depiction and helping us in difficult anatomy examinations. The structures are far crisper and we achieve a greater diagnostic confidence,” he continued.
“The first result that we've obtained using PIQE – which is currently only applicable on 2D MRI sequences – is that you can obtain sharper images without altering the SNR. We get now crisper images," said Dr Savatovsky.
“We feel that we get far more details, which is quite surprising, because it's the same acquisition and the same scan time. In addition of improving SNR, PIQE also increases the matrix resolution, facilitating contour depiction and helping us in difficult anatomy examinations. The structures are far crisper and we achieve a greater diagnostic confidence,” he continued.
Figure 6: Sagittal T2w Dixon images of a 71-year-old patient with cervical spondylotic myelopathy after surgery. The spinal cord residual high-T2 signal abnormalities in C2-C3, C3-C4 and C4-C5 are better depicted on the PIQE reconstructions. In addition, the sharpness of vertebræ, discs and spinal cord has been highly improved.
The future is here
With the experience already gained, Dr. Savatovsky believes some next steps in development might include application of AiCE and PIQE algorithms to more sequences.
“We are confident that Canon Medical is striving towards even further progress and we're really looking forward to this.” //
“We are confident that Canon Medical is striving towards even further progress and we're really looking forward to this.” //
From left to right : Emilie Poiron, PhD (Rothschild Foundation), Julien Savatovsky, MD (Rothschild Foundation), Elsa Guibert (Rothschild Foundation), Bei Zhang, MD (Canon Medical Systems Europe), Jinane Haddad (Canon Medical Systems France), Bruno Triaire (Canon Medical Systems Corporation), Francois Vorms (Canon Medical Systems France), Jean-Claude Sadik, MD (Rothschild Foundation), Morgane Bennamri (Rothschild Foundation), Valentin Prevost, PhD (Canon Medical Systems Corporation), Khadra Fleury (Canon Medical Systems France), Yvonne Purcell, MD (Rothschild Foundation), Thierry Munier (Canon Medical Systems Europe) and Loris Grignion (Canon Medical Systems France)
“We're looking forward applying PIQE in 3D sequences and for low resolution sequences, such as diffusion imaging”
Julien Savatovsky, MD Deputy head of Diagnostic Neuroradiology at the Rothschild Foundation Hospital, Paris, France
Dr. Julien Savatovsky
Dr. Savatovsky is Deputy Head of the Imaging Department (Diagnostic Neuroradiology) at the Rothschild Foundation Hospital, Paris, France.
Dr. Savatovsky continued his undergraduate training in medicine at the University of Paris-VI Pierre and Marie Curie and his internship in Paris. He completed his training with a two-year clinic in the Neuroradiology Department of the Pitié- Salpêtrière hospital group. He continued his hospital career as a hospital practitioner in neuroradiology at the Rothschild Foundation Hospital.
He specializes in nervous system imaging and neck diseases. In order to give access to high quality imaging to patients, Dr. Savatovsky uses specifically optimized 3T MRI equipment and has advanced training in MRI techniques (including sequence development and tuning) and in advanced post-processing.
Dr. Savatovsky is Deputy Head of the Imaging Department (Diagnostic Neuroradiology) at the Rothschild Foundation Hospital, Paris, France.
Dr. Savatovsky continued his undergraduate training in medicine at the University of Paris-VI Pierre and Marie Curie and his internship in Paris. He completed his training with a two-year clinic in the Neuroradiology Department of the Pitié- Salpêtrière hospital group. He continued his hospital career as a hospital practitioner in neuroradiology at the Rothschild Foundation Hospital.
He specializes in nervous system imaging and neck diseases. In order to give access to high quality imaging to patients, Dr. Savatovsky uses specifically optimized 3T MRI equipment and has advanced training in MRI techniques (including sequence development and tuning) and in advanced post-processing.
Rothschild Foundation Hospital, Paris, France
In addition to his clinical work and the management of the Imaging Department, Dr. Savatovsky has been involved in research for several years. He has contributed to over a hundred articles published in international journals.
His main areas of research include:
His main areas of research include:
- the development of new MRI sequences
- imaging of the cerebral lymphatics and the blood-brain barrier
- imaging of idiopathic intracranial hypertension
- multiple sclerosis (MS) imaging, including high resolution sequences, magnetic susceptibility
- innovative post-processing and AI.
Julien Savatovsky, MD
Deputy head of Diagnostic Neuroradiology at the Rothschild Foundation Hospital, Paris, France
Deputy head of Diagnostic Neuroradiology at the Rothschild Foundation Hospital, Paris, France
Valentin H. Prevost, PhD
MR Clinical Scientist
Canon Medical Systems Corporation
MR Clinical Scientist
Canon Medical Systems Corporation
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